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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

SET Protein in Cancer: A Potential Therapeutic Target

Author(s): Xinjie Liang, Xuefei Bao* and Guoliang Chen*

Volume 21, Issue 16, 2021

Published on: 14 January, 2021

Page: [2290 - 2299] Pages: 10

DOI: 10.2174/1389557521666210114163318

Price: $65

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Abstract

SET protein is a multi-functional oncoprotein that is ubiquitously expressed in most tumor cells. Dysregulation of SET has been associated with many types of cancer. Due to ever-accumulating evidence of its strong correlation with both poor prognosis and drug resistance, the targeting of SET is starting to be explored. SET is currently regarded as a potential target for cancer therapy, and several inhibitors are being developed for clinical trials. In this review, the physiological and pathological functions of SET, as well as its antagonists, will be discussed along with the prospects and challenges involved with translating SET inhibitors into bona fide therapeutic options.

Keywords: SET, oncoprotein, dysregulation, cancer, prognosis, resistance, inhibitors.

Graphical Abstract

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