Title:Emerging Role of Terpenoids for the Treatment of Cancer: A Review
Volume: 21
Issue: 16
Author(s): Bhawna Chopra*, Ashwani Kumar Dhingra, Kanaya Lal Dhar and Kunal Nepali
Affiliation:
- Guru Gobind Singh College of Pharmacy, Yamuna Nagar-135001, Haryana,India
Keywords:
Terpenes, biological activity, cancer, isoprene, pathology, history.
Abstract:
Aim: Terpenes are natural compounds found in several organisms belonging to the animal
and plant kingdom, therefore, constitute the largest class of natural products and were a rich reservoir
of candidate compounds for drug discovery. The review aims to focus on the extensive potential of the
anti-cancer terpenoid components obtained from natural plant species which may lead to the development
of a variety of derived terpenoids moieties.
Method: Literature survey has been carried out to determine the potential of terpenoids.
Result: The present article provides an overview of the development of the isoprene unit and the generation
of the various types of terpenes that exhibits pharmacological potential. The anti-cancer activity
of terpenoids appears promising and will potentially open more opportunities for cancer therapy.
However, current studies are restricted to descriptive findings and some of them lack mechanistic insights
and systematic structure--activity relationship studies. Future efforts into the systematic identification
of the targets of terpenoids are believed to increase the chances of gaining breakthrough insights
in the field.
Conclusion: There is still hope that new therapeutic options for the control of cancer and any other
painful syndromes will be developed from terpenes, which were proved to be great candidates for
cancer therapeutics.
