Title:An Updated Review of Various Medicinal Applications of p-Co umaric Acid: From Antioxidative and Anti-Inflammatory Properties to Effects on Cell Cycle and Proliferation
Volume: 21
Issue: 15
Author(s): Mohammad Foad Abazari, Navid Nasiri, Shohreh Zare Karizi, Fatemeh Nejati, Hamed Haghi-Aminjan, Sara Norouzi, Peyman Piri, Leila Estakhr, Davood Rabiei Faradonbeh, Mina Kohandani, Karim Daliri, Nima Sanadgol*Hassan Askari*
Affiliation:
- Department of Biology, Faculty of Sciences, University of Zabol, Zabol,Iran
- Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz,Iran
Keywords:
Apoptosis, human disorders, inflammation, oxidative stress, p-coumaric acid, cell, cycle.
Abstract: P-Coumaric acid (p-CA) is a hydroxycinnamic acid, an organic compound that is a hydroxyl
derivative of cinnamic acid. P-CA is the most abundant isomer in nature and can be found in a wide
variety of edible plants such as fungi, peanuts, navy beans, tomatoes, carrots, basil, and garlic. Recently,
the therapeutic properties of p-CA have received a great deal of attention from scientific society.
Here, we described the medicinal effects of p-CA on various pathological conditions. This review was
performed via evaluating PubMed reported studies from January 2010 to January 2020. Also, reference
lists were checked to find additional studies. All intermediation or complementarity of animal
models, case-control and cohort studies, in vitro studies, and controlled trials (CTs) on p-CA were
acceptable. However plant extract studies without indication of main active substances were excluded
due to the considerable diversities and heterogeneities. According to recent evidence regarding the
beneficial effects of p-CA, numerous diseases such as nephropathies, cardiovascular diseases, neuroinflammatory
diseases, liver diseases, cancers, and some metabolic disorders could potentially be controlled
by this natural herb. Interestingly, autophagy is a novel molecular mechanism involved in the
crosstalk between classic effects of p-CA and introduces alternative therapeutic pathways for this
compound. Much work remains in clarifying the main therapeutic properties among the various p-CA
effects; these will be the subject of forthcoming work, resulting in presenting further mechanism of
action.
