Title:Carotid Arterial Stiffness and Cerebral Blood Flow in Amnestic Mild Cognitive Impairment
Volume: 17
Issue: 12
关键词:
轻度遗忘性认知障碍,颈动脉僵硬,脑灌注不足,脑血管阻力,
搏动性脑血流,经颅多普勒,超声检查。
摘要:
Background: Central arterial stiffness is an emerging risk factor of age-related cognitive
impairment and Alzheimer’s disease (AD). However, the underlying pathophysiological mechanisms
remain unclear.
Objective: We tested the hypothesis that carotid arterial stiffness is associated with reduced cerebral
blood flow (CBF) and increased cerebrovascular resistance (CVR) in patients with amnestic mild cognitive
impairment (MCI), a prodromal stage of AD.
Methods: Fifty-four patients with amnestic MCI and 24 cognitively normal subjects (CN) of similar
age and sex to MCI patients underwent measurements of CBF and carotid β-stiffness index using ultrasonography
and applanation tonometry. Total CBF was measured as the sum of CBF from both the
internal carotid and vertebral arteries, and divided by total brain tissue mass (assessed with MRI) to
obtain normalized CBF (nCBF).
Results: Relative to CN subjects, MCI patients showed lower nCBF (53.3 ± 3.2 vs 50.4±3.4 mL/100
g/min, P < 0.001) and higher CVR (0.143 ± 0.019 vs 0.156 ± 0.023 mmHg/mL/min, P < 0.015). Multiple
linear regression analysis showed that nCBF was negatively associated with carotid β-stiffness
index (B = -0.822, P < 0.001); CVR was positively associated with carotid systolic pressure (B = 0.001,
P < 0.001) after adjustment for age, sex, body mass index, and MCI status.
Conclusion: These findings suggest that carotid artery stiffening may contribute at least in part to the
reduced nCBF and increased CVR in patients with MCI associated with augmented carotid arterial
pulsatility.