Title:Diabetes Mellitus and Renal Function: Current Medical Research and Opinion
Volume: 17
Issue: 9
Author(s): Moyad Shahwan*, Nageeb Hassan, Rima Ahd Shaheen, Ahmed Gaili, Ammar Abdulrahman Jairoun, Monzer Shahwan, Osama Najjar and Shazia Jamshed
Affiliation:
- Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman,United Arab Emirates
Keywords:
Diabetes mellitus, chronic kidney disease, type 2 diabetes mellitus, vitamin D deficiency, high blood glucose level,
kidney function.
Abstract: Diabetes mellitus (DM), which is defined as high blood glucose level, is a major public
health issue worldwide. An enormous amount of data has been gathered regarding DM as populations
have been living with it for more than a decade; however, continually updating our knowledge
of DM remains important. Comorbidities are among the major challenges associated with
DM. Poorly controlled DM, especially type 2 DM (T2DM), is considered a risk factor for many diseases,
including but not limited to chronic kidney disease (CKD). Complications might appear over
time as the aging process changes body functions; moreover, a significant number of antidiabetic
medications are eventually cleared by the kidneys, thereby increasing the burden on kidney function
and placing diabetic patients at risk. The significantly high number of patients with uncontrolled
diabetes resulting from kidney disease shows the impact of this condition on the quality of
life of patients. This review presents an overview of the pathophysiology, etiology, and prevalence
of CKD and abnormal renal parameters correlated with poorly controlled T2DM, with an emphasis
on clinical studies involving the association between vitamin D insufficiency/deficiency and CKD
among patients with T2DM.
