Title:Antioxidant, Anti-inflammatory, Antibacterial, and Analgesic Activities and Mechanisms of Quinolines, Indoles and Related Derivatives
Volume: 21
Issue: 16
Author(s): Shan-Shan Zhang, Qiu-Wan Tan and Li-Ping Guan*
Affiliation:
- Food and Pharmacy College, Zhejiang Ocean University, Zhejiang, Zhoushan 316022,China
Keywords:
Quinoline, isoquinoline, indole, antioxidant, anti-inflammatory, antibacterial, analgesic activity.
Abstract: Quinoline, isoquinoline, and indoles are common heterocyclic compounds. They have
many biological activities, such as antioxidant, anti-inflammatory, antibacterial, antitumor, anti-virus,
anti-rheumatism, immunity regulation, expectorant, and analgesic. Over the past few centuries, traditional
natural products have made great contributions to the discovery and development of new therapeutic
agents. Many important drugs have been found from these three classes of compounds. In this
mini-review, we mainly cover the research progress on antioxidant, anti-inflammatory, antibacterial,
analgesic activities of quinoline, isoquinoline, and indole compounds over the past 20 years (2000-
2019). We aim to explore new characteristic groups or structures in the search for active lead compounds
and provide a basis for rational drug design.
