摘要
传染病是由病原微生物引起的,如细菌、真菌、寄生虫和病毒。此类疾病大多发生在热带和亚热带气候中,代表着重大的健康挑战。这些疾病的病原体能够在人类宿主中繁殖,保证它们的持续生存。由于缺乏有效的疫苗及其治疗方法,预防这些疾病变得极其困难,而由于其致病病原体对现有药物产生抗药性而效果不佳。几种目前可用的药物采用氧化应激,由活性氧氮 (RONS) 的产生产生,作为发挥其药理作用的机制。 RONS 抑制内源性抗氧化酶,最终根除微生物群。姜黄素是一种具有氧化还原活性的天然产物,几个世纪以来,一直被亚洲传统医学用于治疗各种疾病。它以具有多种生物和药理活性而闻名。多年来,姜黄素因其抗炎、抗癌、抗寄生虫、抗病毒和抗菌活性而被广泛研究,并且该化合物没有毒性。尽管具有效力和良好的安全性,姜黄素仍处于临床试验阶段,用于治疗结核病、获得性免疫缺陷综合征 (AIDS)、克罗恩病、结直肠癌和多发性骨髓瘤等许多疾病,因为它尚未有资格作为治疗剂。本综述总结了过去十年中发生的事件,特别是关于姜黄素的发现、其合成的更新、其病原体特异性作用机制以及其衍生物、组合和制剂作为潜在的抗菌剂、抗真菌剂、抗寄生虫剂和抗病毒剂的药理作用用于治疗各种传染病。
关键词: 传染病,氧化还原活性,姜黄素,抗菌,抗真菌,抗寄生虫,抗病毒。
Current Medicinal Chemistry
Title:Recent Advances in the Synthesis and Development of Curcumin, its Combinations and Formulations and Curcumin-like Compounds as Anti-infective Agents
Volume: 28 Issue: 27
关键词: 传染病,氧化还原活性,姜黄素,抗菌,抗真菌,抗寄生虫,抗病毒。
摘要:
Infectious diseases are caused by pathogenic microorganisms, such as bacteria, fungi, parasites and viruses. Such diseases mostly develop in tropical and sub-tropical climates and represent major health challenges. The pathogens of these diseases are able to multiply in human hosts, warranting their continual survival. Prevention of these diseases is becoming extremely difficult due to the absence of effective vaccines and their treatment, less effective due to the emergence of resistance by their causative pathogens to existing drugs. Several currently available drugs employ oxidative stress, resulting from the generation of reactive oxygen nitrogen species (RONS), as the mechanism for exerting their pharmacological actions. RONS inhibit endogenous antioxidant enzymes, which ultimately eradicate the microbiota.
Curcumin, a redox-active natural product, for centuries, has been used in Asian traditional medicine for the treatment of various diseases. It is known for possessing multiple biological and pharmacological activities. Curcumin has been investigated extensively over the years for its anti-inflammatory, anticancer, antiparasitic, antiviral and antibacterial activities, and no toxicity is associated with the compound. Despite its potency and good safety profile, curcumin is still in clinical trials for the treatment of diseases, such as tuberculosis, acquired immunodeficiency syndrome (AIDS), Crohn’s disease, colorectal cancer, and multiple myeloma, among many others, as it is yet to be qualified as a therapeutic agent. This review summarizes events over the last decade, especially regarding the discovery of curcumin, an update of its synthesis, its pathogen specific mechanisms of action, and the pharmacological effects of its derivatives, combinations and formulations as potential antibacterial, antifungal, antiparasitic and antiviral agents for the treatment of various infectious diseases.
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Cite this article as:
Recent Advances in the Synthesis and Development of Curcumin, its Combinations and Formulations and Curcumin-like Compounds as Anti-infective Agents, Current Medicinal Chemistry 2021; 28 (27) . https://dx.doi.org/10.2174/0929867328666210111102916
DOI https://dx.doi.org/10.2174/0929867328666210111102916 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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