Title:Ferulic Acid and Cardiovascular Health: Therapeutic and Preventive Potential
Volume: 21
Issue: 13
Author(s): Evandro Manoel Neto-Neves , Carlos da Silva Maia Bezerra Filho, Naiara Naiana Dejani and Damião Pergentino de Sousa*
Affiliation:
- Department of Pharmaceutical Sciences, Federal University of Paraiba, Joao Pessoa,Brazil
Keywords:
Natural product, foods, oxidative stress, antioxidant, cardioprotection, vasorelaxation.
Abstract: Bioactive compounds found in food and medicinal plants contribute to maintaining health
and treating illnesses. For example, hydroxycinnamic acids, such as ferulic acid, are widely present in
nature and have several pharmacological properties, including antioxidant, anti-inflammatory, and
beneficial effects in parameters of diabetes and hyperlipidemia. The results of studies in animal models
and in vitro experiments of ferulic acid suggest its high therapeutic and preventive potential
against several pathological disorders, such as cardiovascular diseases. Therefore, in this review, the
bioactivities of ferulic acid on the cardiovascular system are described, including the discussion of the
mechanisms of action in the various components of the system. In this review, we discuss the pharmacological
properties of this versatile natural product in aspects of cardiovascular health, including cardioprotective
and antihypertensive actions, and on the metabolism of lipids, diabetes, and thrombosis.
