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Abstract
Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form, derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three-dimensional honeycombs like structure provided with two internal aqueous channels for the incorporation of many s biologically active ingredients. In contrast to liposomes, they provide a large surface area for the incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as a method of choice in the sustained release, controlled release, and targeted release dosage forms as new drug delivery system for the better release of the drugs. As a lot of advancement in the new form of dosage form brought the novel avenues in drug delivery mechanisms, so it was a matter of worth to compile the latest updates on the various aspects of the mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health-related benefits.
Keywords: Cubosome, cubic phase, nanoparticles, bicontinuous, amphiphilic, drug delivery.
Current Drug Metabolism
Title:An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System
Volume: 22 Issue: 6
Author(s): Madhukar Garg, Anju Goyal*Sapna Kumari
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab,India
Keywords: Cubosome, cubic phase, nanoparticles, bicontinuous, amphiphilic, drug delivery.
Abstract: Cubosomes are highly stable nanostructured liquid crystalline dosage delivery form, derived from amphiphilic lipids and polymer-based stabilizers converting it in a form of effective biocompatible carrier for the drug delivery. The delivery form comprised of bicontinuous lipid bilayers arranged in three-dimensional honeycombs like structure provided with two internal aqueous channels for the incorporation of many s biologically active ingredients. In contrast to liposomes, they provide a large surface area for the incorporation of different types of ingredients. Due to the distinct advantages of biocompatibility and thermodynamic stability, cubosomes have remained the first preference as a method of choice in the sustained release, controlled release, and targeted release dosage forms as new drug delivery system for the better release of the drugs. As a lot of advancement in the new form of dosage form brought the novel avenues in drug delivery mechanisms, so it was a matter of worth to compile the latest updates on the various aspects of the mentioned therapeutic delivery system including its structure, routes of applications along with the potential applications to encapsulate variety drugs to serve health-related benefits.
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Cite this article as:
Garg Madhukar , Goyal Anju *, Kumari Sapna , An Update on the Recent Advances in Cubosome: A Novel Drug Delivery System, Current Drug Metabolism 2021; 22 (6) . https://dx.doi.org/10.2174/1389200221666210105121532
DOI https://dx.doi.org/10.2174/1389200221666210105121532 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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