Title:A Therapeutic Journey of 5-Pyrazolones as a Versatile Scaffold: A Review
Volume: 21
Issue: 13
Author(s): Ravinder Sharma, Pooja A. Chawla*, Viney Chawla, Rajeev Verma, Nandita Nawal and Vikas Gupta
Affiliation:
- Department of Pharmaceutical Chemistry and Analysis, ISF College of Pharmacy, GT Road, Moga, Punjab,India
Keywords:
Pyrazolones, anti-inflammatory, anticancer, antidepressant, antidiabetic, coronavirus, structure activity relationship.
Abstract: A sizeable proportion of currently marketed drugs come from heterocycles. The heterocyclic
moiety 5-pyrazolone is well known five-membered ring containing nitrogen. Derivatives of this
wonder nucleus have exhibited activities as diverse as antimicrobial, anti-inflammatory, analgesic,
antidepressant, anticonvulsant, antidiabetic, antihyperlipidemic, antiviral, antitubercular, antioxidant,
anticancer and antiviral, including action against severe acute respiratory syndrome (SARS) or 3C
protease inhibitor. A number of drugs based on this motif have already made it to the market. Standard
texts and literature on medicinal chemistry cite different approaches for the synthesis of 5-
pyrazolones. The present review provides an insight view to 5-pyrazolone synthesis, their biological
profile and structure-activity relationship studies.