Title:AMI and Anabolic-Androgenic Steroids: Case Report with Systematic Review
Volume: 17
Issue: 5
Author(s): Eliana M. Mustafa, Idiberto José Zotarelli Filho*, Victor R. R. Ferreira, Sofia Braile Sabino, Giovanni B. Sternieri, Luiza B. Verdi, Cibele O. V. Queiroz, Bethina C. Sbardellini and Maria C. V. B. Braile-Sternieri
Affiliation:
- Department of Cardiology, Domingo Braile Institute, Rua Luiz Vaz de Camoes, São José do Rio Preto-SP,Brazil
Keywords:
Anabolic-androgenic steroids, cardiovascular disease, atherosclerosis, angioplasty, acute myocardial infarction,
EVR.
Abstract: Introduction: Coronary artery disease (CAD) represents approximately 390 thousand
deaths per year in Brazil and is associated, among other predictors, with the use of anabolic and androgenic
steroids (AAS).
Objective: To analyze a clinical case of a patient who suffered AMI after abuse of AAS. A systematic
literature review has been carried out to physiologically analyze the main factors that can lead
to AMI with the use of these hormones.
Methods: The EVR patient, 41 years old, denies any comorbidities or use of medications. He has
been admitted to the emergency room due to typical angina-precordial pain in tightness associated
with eventual back pain and paresthesia of both upper limbs, after intense physical effort at the
gym, without improvement at rest, and with partial improvement after first care at the health unit.
The patient was hypertensive in an emergency bed after the occurrence of ST elevation. The patient
alleges the use of anabolic steroids for one month. The patient presented with obstructive
atherosclerotic coronary artery disease with total occlusion of the anterior descending artery. Systematic
review: A total of 89 clinical studies have been compared and submitted to eligibility analysis,
with 50 studies selected, according to the PRISMA rules.
Results: Long-term consumption of AAS may cause pathological changes, however, AAS can increase
protein synthesis, muscle growth, and erythropoiesis.
Conclusion: Abuse of AAS has a toxic cardiovascular effect, which significantly increases the incidence
of cardiovascular diseases.
