Title:Advances in the Occurrence of Pyroptosis: A Novel Role in Atherosclerosis
Volume: 22
Issue: 12
Author(s): Jie Yu, Xinghui Cui, Xiaoyun Zhang, Min Cheng and Xiaodong Cui*
Affiliation:
- School of Basic Medicine Sciences, Weifang Medical University, Weifang, Shandong, 261053,China
Keywords:
Pyroptosis, apoptosis, atherosclerosis, vascular endothelial cells, macrophages, vascular smooth muscle cells.
Abstract: Pyroptosis is a new type of pro-inflammatory programmed cell death identified over the
last few years and has since attracted researchers' attention. Current research demonstrates that pyroptosis's
primary process is dependent on caspase-1 protein and gasdermin D protein and is accompanied
by the release of inflammatory substances. However, the specific mechanisms and physiological
or pathophysiological processes involved in pyroptosis are unclear. Presently, research on the occurrence,
development, and treatment of various diseases associated with pyroptosis is of significant
value. Pyroptosis has been implicated in the pathogenesis of atherosclerosis. For instance, numerous
studies have revealed that pyroptosis is involved in the development and progression of atherosclerosis,
and it is closely associated with pyroptosis of three essential cells (vascular endothelial cells,
macrophages, and vascular smooth muscle cells) in atherosclerosis. The advancement of research on
pyroptosis is anticipated to give insights into its application as a potential method for treating diseases.
This article mainly reviews the relationship between pyroptosis and associated mechanisms factors
that cause pyroptosis and the relationship between pyroptosis and various diseases, especially
atherosclerosis.