Title:Therapeutic Properties of Several Chemical Compounds of Salvia officinalis L. in Alzheimer’s Disease
Volume: 21
Issue: 12
Author(s): Georgiana Uță, Denisa Ștefania Manolescu*Speranța Avram
Affiliation:
- Department of Anatomy, Animal Physiology and Biophysics, Faculty of Biology, University of Bucharest, Bucharest,Romania
Keywords:
Salvia officinalis L., alzheimer's disease, natural compounds, therapeutic effects, anti-cancer.
Abstract:
Background: Currently, the pharmacological management of Alzheimer's disease is based
on several chemical structures, represented by acetylcholinesterase and N-methyl-D-aspartate
(NMDA) receptor ligands, with still unclear molecular mechanisms and severe side effects. For this
reason, a challenge for Alzheimer's disease treatment remains to identify new drugs with reduced side
effects. Recently, the natural compounds, particularly, certain chemical compounds identified in the
essential oil of peppermint, sage, grapes, sea buckthorn, have increased interest as possible
therapeutics.
Objectives: In this paper, we have summarized data from the recent literature on several chemical
compounds extracted from Salvia officinalis L., with therapeutic potential in Alzheimer's disease.
Methods: In addition to the wide range of experimental methods performed in vivo and in vitro, we
also presented some in silico studies of medicinal compounds.
Results: Through this mini-review, we presented the latest information regarding the therapeutic
characteristics of natural compounds isolated from Salvia officinalis L. in Alzheimer's disease.
Conclusion: Thus, based on the information presented, we can say that phytotherapy is a reliable
therapeutic method in a neurodegenerative disease.
