Title:Chagas Disease and Coumarins: A Review of Natural and Synthetic Coumarins As Anti-Trypanosoma Cruzi Agents
Volume: 21
Issue: 13
Author(s): Guilherme Arraché Gonçalves*, Hugo Cerecetto, Gilsane Lino von Poser, Rômulo Faria Santos Canto and Vera Lucia Eifler-Lima*
Affiliation:
- Laboratorio de Síntese Organica Medicinal (LaSOM), Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS,Brazil
- Laboratorio de Síntese Organica Medicinal (LaSOM), Programa de Pos-Graduacao em Ciencias Farmaceuticas, Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre/RS,Brazil
Keywords:
Chagas disease, neglected tropical diseases, Trypanosoma cruzi, Trypanosoma cruzi targets, natural coumarins,
synthetic coumarins.
Abstract: The complexity of Chagas disease is still a challenge in endemic regions and an emergent
public health problem in non-endemic countries. The causative agent of this neglected tropical disease,
Trypanosoma cruzi, is mainly transmitted by triatomine vectors and possesses multiple epidemiologically
important strains. Current chemotherapeutics are outdated and their limited efficacy is one
of the major reasons for treatment discontinuation. In this context, the development of novel, safe and
economically accessible antichagasic drugs is required. Various classes of heterocycles and natural
compounds have been described as potential antichagasic scaffolds, and coumarins are no exception.
These versatile compounds have a wide spectrum of biological activities, and numerous natural and
synthetic coumarins have been reported with antichagasic potential. This review aims to discuss the
available literature between 2001 and 2020 regarding natural and synthetic coumarins with anti-
Trypanosoma cruzi activity. Moreover, some of the studies herein comprised are dedicated to the potential
of coumarins to inhibit promising targets in Trypanosoma cruzi.