Title:Potential Epigenetic Targets for Combating Alzheimer’s Disease
Volume: 21
Issue: 12
Author(s): Dheeraj Pandey, Tiyas Pal, Abha Sharma*SJS Flora*
Affiliation:
- Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli,,India
- Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Raebareli,,India
Keywords:
Alzheimer’s, sirtuins, glial cell, epigenetics, DNA methylation, HDACs, MiRNA, Dicer.
Abstract: Memory remains an obligatory regime of the human brain, and impaired memory causes
serious obstacles in our everyday life. Alzheimer’s disease (AD) is one such neurodegenerative disease
which mostly affects the elderly population, above the age of 60; marked by cognitive impairment
of memory. Besides the known targets of AD against the several etiologies known to date, the
zone of epigenetics has recently evolved as an ingenious field in AD. Epigenetic modifications do not
affect DNA sequence but only long-term gene expression. Considering the complex multifactorial
nature of AD, we herein discuss the various epigenetic targets which might give rise to potential therapeutic
approaches. We reviewed the possible epigenetic targets for AD-like HDAC, Sirtuins, glial
cells, miRNA and epigenetic modifications like DNA methylation. A deeper insight into these target
areas can surely evolve AD diagnosis and therapeutics.
