Title:Envisioning the Future of Nanomedicines in Management and Treatment of Neurological Disorders
Volume: 24
Issue: 10
Author(s): Shobhit Kumar*, Priyanka Singh, Shrestha Sharma, Faheem H. Pottoo, Javed Ali and Sanjula Baboota
Affiliation:
- Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology (MIET) NH-58, Delhi- Roorkee Highway, Meerut-250005, Uttar Pradesh,India
Keywords:
Nanomedicines, neurological disorder, nanoparticles, nanocrystals, neurodegenerative disorders, central nervous
system.
Abstract: Neurodegenerative disorders are a result of continuous deterioration of the structure and
function of neurons, involving the death of neurons. Neurodegenerative disorders affect millions of
people around the world. Several conventional drug delivery strategies are available to treat
neurological disorders. However, they are unable to provide adequate cytoarchitecture restoration
and connection patterns due to lower solubility, poor bioavailability, drug resistance and
incapability to traverse the blood-brain barrier (BBB). Therefore, designing and developing new
and efficient delivery systems, that can bring drugs to CNS and have good bioavailability in the
brain is very important. Nano drug delivery system acts as a ray of hope in the diagnosis and
treatment of neurological disorders. The use of nanomedicines encapsulating therapeutic molecules
may enhance transport of drug across BBB, absorption of drug and its controlled release in the
human body with minimum adverse effects. This review article includes a comprehensive
overview of the BBB, recent developments and application of nanomedicines, including liposomes,
nanoparticles, nanomicelles, carbon nanotubes, etc., to the management as well as clinical therapy
of various neurodegenerative disorders.