Title:Benzimidazole as Ubiquitous Structural Fragment: An Update on Development of its Green Synthetic Approaches
Volume: 18
Issue: 8
Author(s): Ashish Patel*, Drashti Shah, Naiya Patel, Khushbu Patel, Nidhi Soni, Afzal Nagani, Vruti Parikh, Hirak Shah and Tushar Bambharoliya
Affiliation:
- Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT-Campus, Changa-388421, Anand, Gujarat,India
Keywords:
Benzimidazole, green chemistry, o-phenylenediamine, aromatic aldehyde, synthesis, sustainable chemistry.
Abstract: Benzimidazole and its derivatives are privileged heterocyclic motifs and important building
blocks for the development of the biologically active compound. However, several research reports are
produced in a short period of time due to the rapid production of new drugs having a benzimidazole
nucleus. In order to understand the current status of the benzimidazole nucleus in medicinal chemistry,
it is therefore important to combine the latest knowledge with earlier information. Hence, synthetic
organic chemists concentrated on inventing an effective green methodology for synthesizing benzimidazole
derivatives. In addition to this, non-degradable chemical compounds cause the ecosystem to
become fragile, damaged, or irritated as contaminants pose a danger to the environment. However,
conventional methods of synthesis need longer heating time, with complicated and tedious apparatus
set up, which results in high cost and pollution in contrast to greener methods which are inexpensive. In
the present review, we have attempted to shed light on various synthetic strategies leading to the synthesis
of different benzimidazole derivatives through the direct condensation reaction between ophenylenediamine
and aromatic aldehydes using green chemistry approaches such as mechanochemistry,
ultrasound irradiation, microwave irradiation, environmentally benign solvents/catalysts, reactant
immobilized on a solid support, and blue light irradiation.
