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摘要
非侵袭性肿瘤/癌症生物标志物的广泛探索为临床诊断提供了思路。然而,许多生物标志物因其敏感性和特异性较低而研究不足,应用潜力有限,相反细胞外载具(EVs)逐渐被认为是有前途的候选药物。EVs 是在多种生理过程和肿瘤/癌症发病过程中在细胞之间运输生物活性物质的小囊泡。本综述旨在提供最近关于 EV 的结构、分类、生理功能以及肿瘤发生和进展变化的研究 。此外,我们还关注了EVs和/或EV相关物质在癌症诊断中的进展,并总结了正在进行的有前景的候选研究,以供未来的研究。
关键词: 细胞外囊泡,癌症诊断,生物标志物,外泌体,肿瘤微环境,微囊泡。
Current Molecular Medicine
Title:Extracellular Vesicles in Tumor Diagnosis: A Mini-Review
Volume: 21 Issue: 7
关键词: 细胞外囊泡,癌症诊断,生物标志物,外泌体,肿瘤微环境,微囊泡。
摘要: Wide exploration of noninvasive tumor/cancer biomarkers has shed light on clinical diagnosis. However, many under-investigated biomarkers showed limited application potency due to low sensitivity and specificity, while extracellular vehicles (EVs) were gradually recognized as promising candidates. EVs are small vesicles transporting bioactive cargos between cells in multiple physiological processes and also in tumor/cancer pathogenesis. This review aimed to offer recent studies of EVs on structure, classification, physiological functions, as well as changes in tumor initiation and progression. Furthermore, we focused on advances of EVs and/or EV-related substances in cancer diagnosis, and summarized ongoing studies of promising candidates for future investigations.
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Cite this article as:
Extracellular Vesicles in Tumor Diagnosis: A Mini-Review, Current Molecular Medicine 2021; 21 (7) . https://dx.doi.org/10.2174/1573405616666201209103154
DOI https://dx.doi.org/10.2174/1573405616666201209103154 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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