Abstract
Wide exploration of noninvasive tumor/cancer biomarkers has shed light on clinical diagnosis. However, many under-investigated biomarkers showed limited application potency due to low sensitivity and specificity, while extracellular vehicles (EVs) were gradually recognized as promising candidates. EVs are small vesicles transporting bioactive cargos between cells in multiple physiological processes and also in tumor/cancer pathogenesis. This review aimed to offer recent studies of EVs on structure, classification, physiological functions, as well as changes in tumor initiation and progression. Furthermore, we focused on advances of EVs and/or EV-related substances in cancer diagnosis, and summarized ongoing studies of promising candidates for future investigations.
Keywords: Extracellular vesicle, cancer diagnosis, biomarker, exosome, tumor microenvironment, microvesicles.
Current Molecular Medicine
Title:Extracellular Vesicles in Tumor Diagnosis: A Mini-Review
Volume: 21 Issue: 7
Author(s): Si Yu, Menglin Huang, Jingyu Wang, Yongchang Zheng*Haifeng Xu*
Affiliation:
- Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing,China
- Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing,China
Keywords: Extracellular vesicle, cancer diagnosis, biomarker, exosome, tumor microenvironment, microvesicles.
Abstract: Wide exploration of noninvasive tumor/cancer biomarkers has shed light on clinical diagnosis. However, many under-investigated biomarkers showed limited application potency due to low sensitivity and specificity, while extracellular vehicles (EVs) were gradually recognized as promising candidates. EVs are small vesicles transporting bioactive cargos between cells in multiple physiological processes and also in tumor/cancer pathogenesis. This review aimed to offer recent studies of EVs on structure, classification, physiological functions, as well as changes in tumor initiation and progression. Furthermore, we focused on advances of EVs and/or EV-related substances in cancer diagnosis, and summarized ongoing studies of promising candidates for future investigations.
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Cite this article as:
Yu Si , Huang Menglin, Wang Jingyu, Zheng Yongchang *, Xu Haifeng *, Extracellular Vesicles in Tumor Diagnosis: A Mini-Review, Current Molecular Medicine 2021; 21 (7) . https://dx.doi.org/10.2174/1573405616666201209103154
DOI https://dx.doi.org/10.2174/1573405616666201209103154 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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