Abstract
Background: Iodination of the organic substrate is an important reaction for the synthesis of pharmacologically active molecules.
Methods: In view of these concerns, we reported a convenient procedure for the synthesis of iodo compounds using iodine and iodic acid in PEG-400. We have reported an eco-friendly procedure for the preparation of aromatic iodo compounds using iodine and iodic acid in green reaction media as polyethylene glycol (PEG-400).
Results: The iodination of some aromatic compounds such as benzaldehydes, acetophenones, phenols, amines, and heterocyclic compounds was carried out using iodine, iodic acid, and PEG-400. The synthesized substituted aromatic iodo compounds were confirmed based on the spectral characterization and mixed melting points.
Conclusion: The method comprises several advantages such as simple reaction procedure, easy isolation, quantitative yields, and purity of iodo products.
Keywords: Iodination, aromatic compounds, iodine, iodic acid, PEG-400, cross-coupling reactions.
Graphical Abstract
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