Title:Understanding The Role of Inflammasome in Angina Pectoris
Volume: 22
Issue: 3
Author(s): Ishita Sharma, Tapan Behl*, Simona Bungau, Monika Sachdeva, Arun Kumar, Gokhan Zengin and Sandeep Arora
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab,India
Keywords:
Angina pectoris, inflammasomes, Nlrp3 inflammasome, coronary artery disease, pyroptosis, cardiovascular disease.
Abstract: Angina pectoris, associated with coronary artery disease, a cardiovascular disease where
the pain is caused by adverse oxygen supply in the myocardium, results in contractility and discomfort
in the chest. Inflammasomes, triggered by stimuli due to infection and cellular stress, have
been identified to play a vital role in the progression of cardiovascular disorders and, thus, causing
various symptoms like angina pectoris. Nlrp3 inflammasome, a key contributor in the pathogenesis
of angina pectoris, requires activation and primary signaling for the commencement of inflammation.
Nlrp3 inflammasome elicits out an inflammatory response by the emission of pro-inflammatory
cytokines by ROS (reactive oxygen species) production, mobilization of K+ efflux and Ca2+ and
by activation of lysosome destabilization that eventually causes pyroptosis, a programmed cell
death process. Thus, inflammasome is considered to be one of the factors involved in the progression
of coronary artery diseases and has an intricate role in the development of angina pectoris.
