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Endocrine, Metabolic & Immune Disorders - Drug Targets


ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

Research Article

The Assessment of Some Metabolic Markers by Combination of Ursolic Acid Supplementation and Resistance Training in Young Older Obese Women

Author(s): Ehsan Asghari, Seyyed Reza Attarzadeh Hosseini, Mina Kiania, Tahereh Farkhondeh, Hamid Arazi and Saeed Samarghandian*

Volume 21, Issue 10, 2021

Published on: 07 December, 2020

Page: [1912 - 1919] Pages: 8

DOI: 10.2174/1871530320666201208105844

Price: $65


Background: In this study, we explored the impacts of moderate-to-high intensity resistance circuit training (MHRCT) and Ursolic acid (UA) supplementation to improve these pathological changes in young older obese women (women between the ages of 50 and 70).

Methods: The study included twenty-five young older women (age > 50 years and ≤70 years) with stage I-II obesity (BMI ≥ 30 and <40 kg/m2), who received eight weeks placebo with MHRCT, and MHRCT with UA supplementation. UA or placebo orally was ingested as a capsule three times per day for eight weeks. The following parameters were evaluated post- and pre-intervention. Data were analyzed using ANOVA with repeated measures.

Results: Interleukin-15 (IL-15), Interleukin-6 (IL-6), Insulin, and HOMA-IR decreased significantly in the placebo and UA groups versus control, but the UA group significantly decreased compared with the placebo (p<0.05). In turn, the Brain-Derived Neurotrophic Factor (BDNF) and Irisin levels showed a significant increase in the placebo and UA groups versus control. However, the BDNF in the UA group significantly increased compared with the placebo (p < 0.05).

Conclusion: We demonstrated that applying resistance training can reverse the pathological changes that may occur with aging and a sedentary lifestyle. Our results showed that UA could enhance the effects of this type of exercise. Therefore, a combination of the resistance training program and UA supplementation may be considered as a novel and influential intervention to metabolic derangements and may also decrease the burden associated with this condition.

Keywords: Aging, BDNF, cytokine, metabolic markers, Irisin, Ursolic acid, resistance training.

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