Title:Bioactive Loaded Lipid-based Nanostructures: A Novel Insight for Age-related Neurodegeneration
Volume: 21
Issue: 9
关键词:
抗氧化、血脑屏障、药物输送、纳米事业、神经变性、氧化应激。
摘要: Substantial affirmation suggested that oxidative stress remains an impelling
target, contributing to initiate and exacerbate the multiple neurological complications in
age-related neurodegeneration (ARN). Factors including gene and environmental toxins
are now becoming the most threatening cause of oxidative stress, which leads to
mitochondrial dysfunction of the neurons that ultimately causes permanent loss of their
functionality. Clinical trials on antioxidants are still in the pipeline to access them as a
potential therapeutic class. But this raised the generosity for not only to investigate the
module of the antioxidant mechanism but also to justify the drug delivery and dose
regimen. Biological barriers, predominantly, Blood-brain barrier (BBB) and rapid firstpass
metabolism, are some of the potential obstacles for the effective targeting of the
therapeutic agent. Bioactive drugs with antioxidant capacity, loaded with lipid-based
Nano career system have revealed to be a novel therapeutic intervention for ARN. The
review will deal with the comprehensive state-of-art methodology for the delivery of
bioactive loaded lipid Nanocarriers to treat neurodegeneration. A systematic analysis of
published reports will help the researchers to understand the role of natural compound
loaded Nanoengineered system in the field of ARN as a potential Nano therapeutic
intervention.
