Title:An Exposition of 11C and 18F Radiotracers Synthesis for PET Imaging
Volume: 14
Issue: 2
Author(s): Priya Saxena, Tarique Mahmood*, Manish Dixit, Sanjay Gambhir and Farogh Ahsan
Affiliation:
- Department of Pharmacology, Faculty of Pharmacy, Integral University, Lucknow, Uttar Pradesh,India
Keywords:
Radionuclide, radiolabeled, positron emission tomography, imaging, radiotracer, radiochemistry.
Abstract: The development of new radiolabeled Positron emission tomography tracers has been extensively
utilized to access the increasing diversity in the research process and to facilitate the development
in research methodology, clinical usage of drug discovery and patient care. Recent advances
in radiochemistry, as well as the latest techniques in automated radio-synthesizer, have encouraged
and challenged the radiochemists to produce the routinely developed radiotracers. Various
radionuclides like 18F, 11C, 15O, 13N 99mTc, 131I, 124I and 64Cu are used for incorporating
into different chemical scaffolds; among them, 18F and 11C tagged radiotracers are mostly explored
such as 11C-Methionine, 11C-Choline, 18F-FDG, 18F-FLT, and 18F-FES. This review is
focused on the development of radiochemistry routes to synthesize different radiotracers of 11C
and 18F for clinical studies.