Title:Applications of Umbilical Cord Derived Mesenchymal Stem Cells in Autoimmune and Immunological Disorders: From Literature to Clinical Practice
Volume: 16
Issue: 4
Author(s): Bahareh Abbaspanah, Samira Reyhani and Seyed H. Mousavi*
Affiliation:
- Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical sciences, Tehran,Iran
Keywords:
Umbilical cord, mesenchymal stem cells, autoimmune disease, stem cell therapies, bone marrow, non-malignant disorders.
Abstract: Mesenchymal Stem Cells (MSCs) enable a novel approach to stem cell therapy. Bone
Marrow (BM) was the first source used in MSCs therapy. However, BM has a number of key limitations
as a source of MSCs, such as the existence of only a small number of MSCs in the tissue;
the painful, ethically problematic, and invasive nature of the associated collection process; and a decrease
in MSC specifications as the age of donors increases. As a result, there has been increasing
scholarly attention towards identifying alternative sources for MSCs. In specific, Umbilical Cord
Mesenchymal Stem Cells (UC-MSCs) have been identified as a valuable source from which MSC
may be obtained with potentially fewer ethical issues. MSCs can regulate the immune response,
promote tissue repair, increase regeneration, and improve anticancer effects. Thus, they are significant
allogenic and autologous representatives for curing malignant and non-malignant disorders. In
this review, therefore, the prospective applications for curing autoimmune disorders will be considered.
