Title:Nano-Neurotherapeutics (NNTs): An Emergent and Multifaceted Tool for CNS Disorders
Volume: 22
Issue: 4
Author(s): Aashish Sharma*, Romila Manchanda, Faheem H. Pottoo and Ghulam Md. Ashraf
Affiliation:
- SFI Centre for Research in Medical Devices (CÚRAM), National University of Ireland, Galway,Ireland
Keywords:
Nanoparticles, BBB, neuronal disorders, imaging, theranostics, drug delivery, cancer.
Abstract: Impressive research steps have been taken for the treatment of neurological disorders in the last few
decades. Still, effective treatments of brain related disorders are very less due to problems associated with crossing
the blood-brain barrier (BBB), non-specific therapies, and delay in functional recovery of the central nervous
system (CNS) after treatment. Striving for novel treatment options for neurological disorders, nanotechnology-
derived materials, and devices have gained ground due to inherent features of derivatization/encapsulation
with drugs as per the neurological ailments and pharmacological targets. Facile developments/syntheses of the
nanomaterials-drug conjugates have also been the driving force for researchers to get into this field. Moreover,
the tunable size and hydro/lipophilicity of these nanomaterials are the added advantages that make these materials
more acceptable for CNS disorders. These nano-neurotherapeutics (NNTs) systems provide the platform
for diagnosis, theranostics, treatments, restoration of CNS disorders, and encourage the translation of NNTs
from “bench to bedside”. Still, these techniques are in the primary stages of medical development. This review
describes the latest advancements and future scenarios of developmental and clinical aspects of polymeric
NNTs.
