Title:Serum Pro-oxidant-antioxidant Balance in Subjects with Type 2 Diabetes Mellitus
Volume: 24
Issue: 9
Author(s): Mahsa Ahmadnezhad*, Hamideh Ghazizadeh*, Moniba Bijari*, Mohammad Reza Oladi*, Habibollah Esmaily, Seyed Javad Hoseini, Elham Barati, Samaneh Silakhori, Maryam Mohammadi-Bajgiran, Hafezeh Davari, Mohammad Reza Parizadeh, Naghme Mokhber, Payam Sharifan, Seyed Rafie Aref-Hosseini, Gordon A Ferns, Mohsen Moohebati and Majid Ghayour-Mobarhan
Affiliation:
- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran
- Student Research Committee, Mashhad University of Medical Sciences, Mashhad,Iran
- Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad,Iran
- International UNESCO Center for Health- Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences, Mashhad,Iran
Keywords:
Pro-oxidant-Antioxidant balance, Type 2 diabetes mellitus, MASHAD cohort study, oxidative stress, inflammation.
Abstract: Aim and Objective: Diabetes mellitus is associated with inflammation and increased
oxidative stress. In the current study, we aimed to investigate the relationship between type 2
diabetes mellitus (T2DM) and serum pro-oxidant-antioxidant balance (PAB) in a large populationbased
study.
Methods: In this cross-sectional study, 7888 individuals were recruited as part of the Mashhad
Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study. Participants were divided
into three groups based on their serum PAB values (levels < 36.4, 36.4-82.6 and > 82.6 HK).
Serum PAB values were measured using a colorimetric method and enzyme-linked immune
sorbent assay (ELISA).
Results: Serum PAB in subjects with and without diabetes was reported 76.85 ± 61.07 HK and
69.51 ± 55.50 HK. In subjects with a serum PAB > 82.6 HK the risk of T2DM was 1.2 fold higher
in comparison to subjects with a serum PAB < 36.4 HK (OR: 1.26, 95% CI: 1.09 – 1.47, P-value:
0.002). This association remained significant after adjustment for confounding factors in
multivariable analysis (OR: 1.19, 95% CI: 1.02 – 1.38, P-value: 0.027).
Conclusion: Increased pro-oxidant levels may be a major complication of T2DM in our study
subjects and PAB could be an indicator of higher oxidative stress in T2DM patients from
northeastern Iran.