摘要
HOX基因属于高度保守的同源盒超家族,负责调控从胚胎发生到癌变等控制细胞稳态的各种细胞过程。HOX基因的异常表达在包括乳腺癌在内的各种癌症中都可以观察到,根据情况,HOX基因可以作为癌基因或作为癌抑制因子。本文基于HOX基因座的三维基因组结构,分析了HOX基因在乳腺癌中的表达模式,并分析了它们之间的关系。本文综述了HOX簇内非编码RNA的存在以及这些分子在乳腺癌中的作用。我们进一步评价了HOX蛋白在乳腺癌中的特征活性及其治疗潜力。
关键词: HOX基因,HOX簇,非编码RNA,基因组组织,3D结构,HOX蛋白,乳腺癌。
Current Medicinal Chemistry
Title:Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer
Volume: 28 Issue: 25
关键词: HOX基因,HOX簇,非编码RNA,基因组组织,3D结构,HOX蛋白,乳腺癌。
摘要: HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer, where they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs embedded within the HOX cluster and the role of these molecules in breast cancer, have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.
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Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867327666201102115327
DOI https://dx.doi.org/10.2174/0929867327666201102115327 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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