Abstract
Applications of Wittig and aza-Wittig reactions in various cyclizations reported during the past ten years are reviewed. The relevant literature is classified into two categories according to these two main approaches and, in both sections, the chemistry is exemplified according to the ring types synthesized. The chemical examples include both intramolecular ring closures and multistep procedures. Within the aza-Wittig reactions, special attention is paid to those products that can undergo electrocyclization to yield nitrogen heterocycles (e.g. pyridines or pyrimidines). In most interesting cases, the reaction mechanism of the transformations is discussed.
Keywords: Carbocycles, intramolecular Wittig reaction, N-Heterocycles synthesis, Cyclizations, Pyrimidine Derivatives, Electrocyclizations
Current Organic Chemistry
Title: Ring Closure Reactions in Heterocyclic Systems with Implementation of Wittig and aza-Wittig Reactions
Volume: 12 Issue: 1
Author(s): Gyorgy Hajos and Ildiko Nagy
Affiliation:
Keywords: Carbocycles, intramolecular Wittig reaction, N-Heterocycles synthesis, Cyclizations, Pyrimidine Derivatives, Electrocyclizations
Abstract: Applications of Wittig and aza-Wittig reactions in various cyclizations reported during the past ten years are reviewed. The relevant literature is classified into two categories according to these two main approaches and, in both sections, the chemistry is exemplified according to the ring types synthesized. The chemical examples include both intramolecular ring closures and multistep procedures. Within the aza-Wittig reactions, special attention is paid to those products that can undergo electrocyclization to yield nitrogen heterocycles (e.g. pyridines or pyrimidines). In most interesting cases, the reaction mechanism of the transformations is discussed.
Export Options
About this article
Cite this article as:
Hajos Gyorgy and Nagy Ildiko, Ring Closure Reactions in Heterocyclic Systems with Implementation of Wittig and aza-Wittig Reactions, Current Organic Chemistry 2008; 12 (1) . https://dx.doi.org/10.2174/138527208783330082
DOI https://dx.doi.org/10.2174/138527208783330082 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Electrochemical C-X bond formation
Conventional methods for carrying out carbon–X bond formation are typically conducted at harsh reaction conditions, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of ...read more
From Lab Bench to Algorithm: The Future of Organic Chemistry Powered by AI
Organic chemistry, with its intricate dance of molecules and reactions, is undergoing a transformation fuelled by the power of Artificial Intelligence (AI) and Machine Learning (ML). The integration of AI/ML with Organic Chemistry is revolutionizing the field by enhancing the efficiency and accuracy of chemical research and development. These technologies ...read more
Related Journals
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements