Abstract
This review deals with synthetic methods, chemical transformations, and some physical properties of thienyland benzothienyl substituted phosphorus compounds bearing P-Het or P-CH2-Het bonds. The basic synthetic approaches to these compounds include reactions of metalated thiophenes with phosphorus(III) and (V) halides, phosphorylation of thiophenes in the presence of a mild Lewis acid, use of halogenothiophenes in the Arbuzov reaction, and phosphorylation of thiophenes with phosphorus(III) halides in basic medium. Synthetic approaches to condensed heterocyclic systems of novel types are also considered. Investigation of chemical properties of phosphorylated thiophenes has revealed that, despite the great similarity with phenyl analogues, differences connected to the nature of the heterocycle are observed. The tertiary phosphines bearing at least one thienyl substituent are less active in quaternization and oxidation reactions. At the same time, basic hydrolysis leading to C-P bond cleavage is facilitated, as compared to benzene derivatives.
Keywords: Metalated Thiophenes, Phosphorus Tribromide, Friedel-Crafts Reaction, Halogenothiophenes, Arbuzov Reaction, Hydrophosphorylation
Current Organic Chemistry
Title: Phosphorylation of Thiophenes
Volume: 12 Issue: 1
Author(s): Sergei P. Ivonin, Andrey A. Tolmachev and Alexander M. Pinchuk
Affiliation:
Keywords: Metalated Thiophenes, Phosphorus Tribromide, Friedel-Crafts Reaction, Halogenothiophenes, Arbuzov Reaction, Hydrophosphorylation
Abstract: This review deals with synthetic methods, chemical transformations, and some physical properties of thienyland benzothienyl substituted phosphorus compounds bearing P-Het or P-CH2-Het bonds. The basic synthetic approaches to these compounds include reactions of metalated thiophenes with phosphorus(III) and (V) halides, phosphorylation of thiophenes in the presence of a mild Lewis acid, use of halogenothiophenes in the Arbuzov reaction, and phosphorylation of thiophenes with phosphorus(III) halides in basic medium. Synthetic approaches to condensed heterocyclic systems of novel types are also considered. Investigation of chemical properties of phosphorylated thiophenes has revealed that, despite the great similarity with phenyl analogues, differences connected to the nature of the heterocycle are observed. The tertiary phosphines bearing at least one thienyl substituent are less active in quaternization and oxidation reactions. At the same time, basic hydrolysis leading to C-P bond cleavage is facilitated, as compared to benzene derivatives.
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Cite this article as:
Ivonin P. Sergei, Tolmachev A. Andrey and Pinchuk M. Alexander, Phosphorylation of Thiophenes, Current Organic Chemistry 2008; 12 (1) . https://dx.doi.org/10.2174/138527208783330073
DOI https://dx.doi.org/10.2174/138527208783330073 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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