摘要
严重急性呼吸系统综合征(SARS)是由冠状病毒(CoV)引起的严重呼吸系统疾病。可用的抗病毒药物或宿主特异性抗炎治疗是主要的治疗方式,药物重新利用作为及时应对冠状病毒大流行最可行的方法。虽然这些方法在一定程度上在降低死亡率方面取得了成功,但要想完全摆脱目前的SARSCoV-2大流行还太远了。植物是饮食、膳食补充剂、植物性药物和天然产物(NPs)的主要来源。它已经被广泛接受,并通过一些科学研究证明,植物性疗法在管理这类感染中发挥着至关重要的作用。有缺陷的免疫系统(先天免疫受损或异常的免疫激活)决定了CoV-2感染患者呼吸窘迫的严重程度。天然产物在病毒复制周期的不同阶段进行干预,包括抑制病毒进入宿主细胞,抑制丝氨酸/半胱氨酸蛋白酶、RNA依赖的RNA聚合酶(RdRp)或解旋酶。此外,一些天然产品或植物性膳食补充剂具有增强免疫系统或缓解超炎症状况的独特能力。许多植物性配方、膳食补充剂和np正在CoV-2感染者的临床试验中进行研究,很少有已经显示出积极的结果。这篇综述发现了一些药物化学项目中的NP线索,以及一些有直接机会在SARS冠状病毒感染中重新利用。
关键词: SARS、冠状病毒、CoV-2、膳食补充剂、天然产品、缓解剂、Covid-19。
Current Medicinal Chemistry
Title:Natural Products in Mitigation of SARS CoV Infections
Volume: 28 Issue: 22
关键词: SARS、冠状病毒、CoV-2、膳食补充剂、天然产品、缓解剂、Covid-19。
摘要: Severe acute respiratory syndrome (SARS) is a critical respiratory disease caused by coronaviruses (CoV). The available antiviral agents or host-specific antiinflammatory therapies are the principal treatment modalities, with drug-repurposing as the most viable approach to timely tackle the CoV pandemic. Though these approaches are successful to some extent in reducing the mortality rate, however, it is too far to see a complete escape from the current SARS CoV-2 pandemic. Plants are the primary source of diet, dietary supplements, botanical drugs, and natural products (NPs). It has been well accepted and proved via several scientific studies that plant-based therapies play a vital role in managing such infections. The faulty immune system (compromised innate immunity or aberrant immune activation) determines the severity of the respiratory distress in CoV-2 infected patients. Natural products intervene at various stages of the virus replication cycle, including inhibition of virus entry into the host cells, inhibition of serine/ cysteine proteases, RNA-dependent RNA polymerase (RdRp) or helicase. Besides, several natural products or plant-based dietary supplements have a unique ability to strengthen the immune system or alleviate the hyper-inflammatory condition. Many plant-based formulations, dietary supplements, and NPs are being investigated in clinical trials in CoV-2 infected patients, and few have already shown positive results. The review has unearthed several NP leads for medicinal chemistry programs as well as some having direct opportunity of repurposing in SARS CoV infections.
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Natural Products in Mitigation of SARS CoV Infections, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327666201027153940
DOI https://dx.doi.org/10.2174/0929867327666201027153940 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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