摘要
背景:2019年新型冠状病毒(2019-nCoV),也被称为冠状病毒2(SARS-CoV-2)急性呼吸系统综合征最近出现,并继续迅速传播,死亡率和发病率较高。目前,还没有有效的治疗方法来缓解冠状病毒感染。由于新药的设计和开发需要时间,现有的抗病毒药物有可能获得有效的治疗方法。 目的:本研究旨在探讨抗病毒药物可能的药物靶点与抗病毒药物作用机制之间的关系。本文综述了从已知分子或新分子中开发药物的努力。 方法:病毒通常具有两种结构完整性,蛋白质和核酸,这两者都可能是可能的药物靶点。在此,我们系统地讨论了刺突、3-糜蛋白酶样蛋白酶(3CLpro)、木瓜蛋白酶样蛋白酶(PLpro)和RNA依赖RNA聚合酶(RdRp)的结构-功能关系,因为这些都是该冠状病毒的显著结构特征。某些抗病毒药物,如雷德西韦是RNA依赖的RNA聚合酶,或具有能力通过抑制ATP来终止RNA复制。 结果:据报道,ATP参与了3CLpro和PLpro的冠状病毒非结构蛋白的合成。同样,本综述也讨论了许多其他抗病毒药物的作用机制。这将为其抑制机制提供新的见解,并让我们开发新的针对新型SARS-CoV-2冠状病毒的抗病毒治疗方法。 结论:综上所述,本文综述了SARS-CoV-2蛋白酶抑制剂的研究进展。
关键词: 冠状病毒、蛋白酶样3-糜蛋白酶(3CLpro)、蛋白酶样木瓜蛋白酶(PLpro)、瑞德西韦、SARSCoV2、非结构蛋白、ATP。
Current Medicinal Chemistry
Title:Recent Advances Towards Drug Design Targeting the Protease of 2019 Novel Coronavirus (2019-nCoV)
Volume: 28 Issue: 22
关键词: 冠状病毒、蛋白酶样3-糜蛋白酶(3CLpro)、蛋白酶样木瓜蛋白酶(PLpro)、瑞德西韦、SARSCoV2、非结构蛋白、ATP。
摘要:
Background: The 2019 novel coronavirus (2019-nCoV), also known as coronavirus 2 (SARS-CoV-2) acute respiratory syndrome has recently emerged and continued to spread rapidly with high mortality and morbidity rates. Currently, no efficacious therapy is available to relieve coronavirus infections. As new drug design and development takes time, there is a possibility offindingan effective treatment from existing antiviral agents.
Objective: The aim of this study is to find out the relationship between thepossible drug targets and themechanism of action of antiviral drugs. This review discusses the efforts indevelopingdrug from known or new molecules.
Methods: Viruses usually have two structural integrities, proteins and nucleic acids, both of which can be possible drug targets. Herein, we systemically discuss the structural-functional relationships of the spike, 3-chymotrypsin-like protease (3CLpro), papain like protease (PLpro) and RNA-dependent RNA polymerase (RdRp), as these are prominent structural features of thecoronavirus. Certain antiviral drugs such as Remdesivir are RNA-dependent RNA polymerase inhibitorswiththe ability to terminate RNA replication by inhibiting ATP.
Results: It is reported that ATP is involved in synthesis of coronavirus non-structural proteins from 3CLpro and PLpro. Similarly, mechanisms of action of many other antiviral agents havebeen discussed in this review. It will provide new insights into the mechanism of inhibition, and let us develop new therapeutic antiviral approaches against novel SARS-CoV-2 coronavirus.
Conclusion: In conclusion, this review summarizes recent progress in developing protease inhibitors for SARS-CoV-2.
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Cite this article as:
Recent Advances Towards Drug Design Targeting the Protease of 2019 Novel Coronavirus (2019-nCoV), Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327666201027153617
DOI https://dx.doi.org/10.2174/0929867327666201027153617 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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