Title:Understanding the Concept of Chronotherapeutics in the Management of Diabetes Mellitus
Volume: 17
Issue: 5
Author(s): Shilpi Kashyap, Rajni Bala*Tapan Behl
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab,India
Keywords:
Chronotherapeutics, diabetes, glucose responsive, cardiovascular, insulin, circadian rhythms.
Abstract: The circadian rhythms have been controlled with the aid of a circadian clock in the hypothalamus
region, which is known as the suprachiasmatic nucleus. Chronotherapeutics, a branch
of pharmacotherapeutics, plays a mandatory role in the treatment of various disorders, such as delivering
the drug in the correct schedule, correct site, and correct extent and provides benefit to the
patients. The chronopharmacological aspects are very much important in the treatment of diabetes
mellitus during daytime as the patients’ timing of daily activities of body and medicine treatment
has an impact on the increase in the glucose levels in the blood. This leads to the fact that the increased
risk of obesity and diabetes gets worse, ultimately increasing the rates of cardiovascular diseases
and deaths. According to a medical saviour who works on the problems related to diabetes,
the level of glucose in plasma changes independently as regard to eating habits and use of insulin
and medicines. People suffering from dawn phenomenon are difficult to manage, hence, the basic
aim is to detect the functioning of the biological clock of human body and its chronotherapeutic effect
on human beings that increases the therapeutic effects and reduces side effects. Keeping these
points in mind, an attempt has been made in the present review to discuss the role of chronotherapy
in the management of diabetes, various techniques used in formulation and design of chronotherapeutic
drug delivery systems and regulatory issues related to chronotherapeutics.
