Title:Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives
Volume: 18
Issue: 6
Author(s): Subramaniyan Arulmurugan, Helen P. Kavitha*Jasmine P. Vennila
Affiliation:
- Department of Chemistry, SRM Institute of Science and Technology, Ramapuram Campus, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu,India
Keywords:
Benzoxazole, synthesis, antimicrobial activity, anti-inflammatory activity, anticancer activity, antitubercular
activity.
Abstract: Benzoxazole compounds have an important and broad range of biological activities. The
benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic,
anti-parasitic, herbicidal, anti-allergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic,
HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have
a binding affinity to Aβ42 fibrils. Such complex biological uses of benzoxazole compounds have inspired
new efforts to find new derivatives with improved biological activity and different applications
in the pharmaceutical industry. Due to outstanding relevance of this structure, the purpose of this analysis
is to highlight aspects published in recent years (2000-2020) on the chemistry and biological activity
of benzoxazoles.