Title:Pharmacologic Evidence of Green Tea in Targeting Tyrosine Kinases
Volume: 16
Issue: 3
Author(s): Joyce T.S. Li, Kam L. Hon*, Alexander K.C. Leung and Vivian W.Y. Lee
Affiliation:
- Department of Paediatrics, The Chinese University of Hong Kong; 6/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin,Hong Kong
Keywords:
Cancer, green tea, tyrosine kinase, targeted therapy, multiple signalling pathways, synergistic effects.
Abstract:
Background: Green tea has been extensively studied for its potential health benefits against
diseases, such as cancers, cognitive degenerative diseases, and cardiovascular diseases.
Methods: The authors undertook a structured search of peer-reviewed research articles from three databases
including PubMed, Embase, and Ovid MEDLINE. Recent and up-to-date studies relevant to
the topic were included.
Results: Green tea extract exerts its functions by interacting with multiple signalling pathways in human
cells. Protein tyrosine kinase is one of the examples. Abnormal activation of tyrosine kinase is
observed in some tumour cells. Green tea extract inhibits phosphorylation, reduces expression, or attenuates
downstream signalling of epidermal growth factor receptor, insulin-like growth factor receptor,
vascular endothelial growth factor receptor, and non-receptor tyrosine kinase. Combination of
green tea extract with tyrosine kinase inhibitors may provide synergistic effects by overcoming acquired
resistance.
Conclusion: Green tea extract can affect multiple receptor targets. In the current review, we discuss
the pharmacological mechanisms of green tea on tyrosine kinases and their implications on common
diseases.
