Title:Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson’s Disease
Volume: 22
Issue: 6
关键词:
帕金森病，多巴胺，天然产物，草药，天然神经保护剂，神经退行性变
摘要: Parkinson’s disease is one of the most common adult-onset, a chronic disorder involving
neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia
nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia,
and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset
of Parkinson’s disease. The exact pathogenesis of Parkinson's disease is quite complicated and the
present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches
have demonstrated the use of natural products such as ginseng, curcumin, ashwagandha,
baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited
by these natural products are mainly due to their ability to increase dopamine levels in the striatum,
manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of α-
synuclein, induce autophagy and decrease the pro-inflammatory cytokines and lipid peroxidation.
This paper reviews various natural product studies conducted by scientists to establish the role of
natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective
agents.
