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摘要
疼痛是一种不愉快的感觉,其病因复杂多样。现代药物发现的重点是识别针对多种途径的潜在分子,与那些针对单一目标的分子相比,这些分子具有更安全的特性。目前可用的治疗方法对疼痛和炎症的治疗有一些主要的副作用。疼痛是需要多靶点、低毒的功能性治疗的主要临床问题之一。姜黄素,一种从姜黄中提取的天然多酚化合物,多年来一直被用于印度草药、中药和许多其他传统医学体系中。目前已发表的临床前数据表明,姜黄素具有多靶点生物学功能,提示其具有治疗不同疾病的潜力。然而,对于其在疼痛和炎症方面的潜在应用以及这些活动的潜在机制,目前还没有或非常简短的系统综述。因此,本文综述的目的是更新姜黄素及其镇痛和抗炎作用的多靶点通路的临床前数据,并进一步提出其分子机制。一项文献研究使用了Pubmed、SciFinder、谷歌Scholar和Science Direct等不同的已知数据库。现有的临床前数据表明,姜黄素对疼痛和炎症的改善作用是通过调节疼痛途径实现的,包括抑制一些促炎症介质,抑制氧化应激和环氧合酶-2 (COX-2),下调Ca2+/钙调素依赖蛋白激酶II (CaMKIIα)和钙通道如瞬时受体电位(TRP),调节代谢型谷氨酸受体2 (mGlu2),调节单胺系统,抑制JAK2/STAT3信号通路,重构细胞外基质蛋白,抑制细胞凋亡,抑制JNK/MAPK和ERK/CREB信号通路,激活阿片系统。综上所示,姜黄素是一种很有前途的、安全的、天然的多酚分子,能够靶向疼痛的多个分子途径,有助于疼痛和炎症的治疗和管理。
关键词: 姜黄素,多靶点药理,姜黄,疼痛,炎症,植物成分
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