Title:Antibiotic Potentiation of Natural Products: A Promising Target to Fight Pathogenic Bacteria
Volume: 22
Issue: 5
关键词:
抗生素，抗菌耐药性，药用植物，精油，细菌生物膜，协同作用，微生物。
摘要: Pathogenic microorganisms should be considered as the number one foe of human, as
witnessed by recent outbreaks of coronavirus disease (COVID-19) and with bacteria no longer sensitive
to existing antibiotics. The resistance of pathogenic bacteria and deaths attributable to bacterial
infections is increasing exponentially. Bacteria used different mechanisms to counterattack to
existing antibiotics, namely (i) enzymatic inhibition, (ii) penicillin-binding protein modification, (iii)
porin mutations, (iv) efflux pumps and (v) molecular modifications of antibiotic targets. Developing
new antibiotics would be time-consuming to address such a situation, thus one of the promising
approaches is by potentiating existing antibiotics. Plants used synergism to naturally defend and
protect themselves from microbes. Using the same strategy, several studies have shown that the
combinations of natural products and antibiotics could effectively prolong the lifespan of existing
antibiotics and minimize the impact and emergence of antibiotic resistance. Combining essential
oils constituents, namely uvaol, ferruginol, farnesol and carvacrol, with antibiotics, have proved to
be efficient efflux pump inhibitors. Plant-derived compounds such as gallic acid and tannic acid
are effective potentiators of various antibiotics, including novobiocin, chlorobiocin, coumermycin,
fusidic acid, and rifampicin, resulting in a 4-fold increase in the potencies of these antibiotics. Several
lines of research, as discussed in this review, have demonstrated the effectiveness of natural
products in potentiating existing antibiotics. For this reason, the search for more efficient combinations
should be an ongoing process with the aim to extend the life of the ones that we have and
may preserve the life for the ones that are yet to come.
