Title:A Review on Mechanistic and Pharmacological Findings of Diabetic Peripheral Neuropathy including Pharmacotherapy
Volume: 17
Issue: 3
Author(s): Ruchi Tiwari*, Pranay Wal, Priya Singh, Gaurav Tiwari and Awani Rai
Affiliation:
- Department of Pharmacy, Pranveer Singh Institute Of Technology, Kanpur - Agra - Delhi National Highway - 2 , Bhauti - Kanpur – 209305,India
Keywords:
Diabetic peripheral neuropathy, pathogenesis of DPN, available treatments, pathogenetic treatments, symptomatic
treatments, herbal treatments, supporting literatures.
Abstract: Background: Chronic hyperglycemia and related complications involving peripheral
nerves in diabetes are one of the most severe microvascular complications with an average prevalence
of 50–60%. Diabetic neuropathy is among the vascular disorders of diabetes, the most debilitating
and crippled, lethal condition impacting patients’s quality of life.
Methods: In the present review article, several hypotheses associated with the pathogenesis of Diabetic
Peripheral Neuropathy (DPN) have been introduced, among them metabolic pathways associated
with polyol pathway, oxidative stress, production of reactive oxygen species (ROS) amplified
under chronic hyperglycemic conditions and activation of transcription factor Nuclear factor-κB (NF-
κB). The review article also possesses pathogenetic and pharmacologic treatments along with
others, including acupressure, lidocaine, and capsaicin for DPN.
Conclusion: It may be concluded that we can combat the pathogenesis of DPN with different
suggested treatments.
