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Abstract
In the last 20 years, N-Heterocyclic Carbene (NHC) ligands have been ubiquitous in biological and medicinal chemistry. Part of their success lies in the tremendous number of topologies that can be synthesized and thus finely tuned that have been described so far. This is particularly true in the case of those derivatives, including fluorine or fluorinated fragments on their NHC moieties, gaining much attention due to their enhanced biological properties and turning them into excellent candidates for the development of novel metallodrugs. Thus, this review summarizes the development that fluorinated-NHC transition metal complexes have had and their impact on cancer treatment.
Keywords: Cytotoxicity, fluorinated complexes, NHC complexes, cancer, N-heterocyclic Carbene (NHC), fluorine, metallodrugs.
[http://dx.doi.org/10.3322/caac.21492] [PMID: 30207593]
[http://dx.doi.org/10.1007/s00280-016-2976-z] [PMID: 26886018]
[http://dx.doi.org/10.2174/1566524013666131111125515] [PMID: 24206132]
[http://dx.doi.org/10.1016/S0027-5107(01)00141-5] [PMID: 11406167]
[http://dx.doi.org/10.1016/S0027-5107(01)00142-7] [PMID: 11406166]
[http://dx.doi.org/10.2174/0929867033368484] [PMID: 12570712]
[http://dx.doi.org/10.1016/j.ejphar.2014.07.025] [PMID: 25058905]
[http://dx.doi.org/10.1007/BF00685326] [PMID: 8261581]
[http://dx.doi.org/10.1007/978-3-030-20301-6_13]
[http://dx.doi.org/10.2174/0929867324666170112095428] [PMID: 28079002]
[http://dx.doi.org/10.1038/s41467-017-01837-1] [PMID: 29162831]
[http://dx.doi.org/10.1021/acs.chemrev.5b00597] [PMID: 26865551]
[http://dx.doi.org/10.1039/C7CS00332C] [PMID: 29170783]
[http://dx.doi.org/10.1039/C7CS00195A] [PMID: 28654103]
[http://dx.doi.org/10.1039/B707077M] [PMID: 19169456]
[http://dx.doi.org/10.2174/156802611798040769] [PMID: 22039871]
[http://dx.doi.org/10.1021/cr400135x] [PMID: 24102434]
[http://dx.doi.org/10.1021/acs.chemrev.8b00396] [PMID: 30489072]
[http://dx.doi.org/10.1021/cr400460s] [PMID: 24456146]
[http://dx.doi.org/10.1039/c002475a] [PMID: 20495733]
[http://dx.doi.org/10.1021/jm100020w] [PMID: 21077686]
[http://dx.doi.org/10.1016/j.cbpa.2012.01.013] [PMID: 22366385]
[http://dx.doi.org/10.1039/C5CS00132C] [PMID: 25868756]
[http://dx.doi.org/10.1021/acs.jmedchem.7b01689] [PMID: 29446940]
[http://dx.doi.org/10.1016/j.ccr.2016.09.004]
[http://dx.doi.org/10.1039/C2CS35314H] [PMID: 23147001]
[http://dx.doi.org/10.1039/C4DT00624K] [PMID: 24770329]
[http://dx.doi.org/10.1039/C2DT32617E] [PMID: 23223752]
[http://dx.doi.org/10.1016/j.cbpa.2017.10.014] [PMID: 29136524]
[http://dx.doi.org/10.1021/acs.chemrev.7b00778] [PMID: 29608052]
[http://dx.doi.org/10.1021/acs.chemrev.9b00024] [PMID: 31436087]
[http://dx.doi.org/10.1021/cr4002879] [PMID: 24299176]
[http://dx.doi.org/10.1021/acs.chemrev.5b00392] [PMID: 26756377]
[http://dx.doi.org/10.1016/j.jfluchem.2006.01.011]
[http://dx.doi.org/10.1016/j.jfluchem.2006.06.007]
[http://dx.doi.org/10.1039/C4CS00343H] [PMID: 25724019]
[http://dx.doi.org/10.3390/molecules24101995] [PMID: 31137659]
[http://dx.doi.org/10.3390/molecules25020265] [PMID: 31936496]
[http://dx.doi.org/10.3390/ph12040146] [PMID: 31561546]
[http://dx.doi.org/10.2174/092986706776360941] [PMID: 16611086]
[http://dx.doi.org/10.1021/acs.chemrev.8b00271] [PMID: 30640441]
[http://dx.doi.org/10.1021/jm050015d] [PMID: 15943488]
[http://dx.doi.org/10.1016/j.jinorgbio.2008.05.004] [PMID: 18582946]
[http://dx.doi.org/10.1007/s00775-008-0400-9] [PMID: 18597125]
[http://dx.doi.org/10.1039/C4DT02764G] [PMID: 25407500]
[http://dx.doi.org/10.1021/bm4013919] [PMID: 24266669]
[http://dx.doi.org/10.1007/s00894-012-1683-x] [PMID: 23187687]
[http://dx.doi.org/10.1039/C2DT32333H] [PMID: 23187957]
[http://dx.doi.org/10.1021/jm301103y] [PMID: 22991922]
[http://dx.doi.org/10.3390/ijms131013183] [PMID: 23202946]
[http://dx.doi.org/10.1021/jm2002074] [PMID: 21534534]
[http://dx.doi.org/10.1039/b909185h] [PMID: 21305148]
[http://dx.doi.org/10.1007/s00775-009-0489-5] [PMID: 19288144]
[http://dx.doi.org/10.1016/j.jinorgbio.2008.08.002] [PMID: 18834634]
[http://dx.doi.org/10.1021/acs.inorgchem.9b01203] [PMID: 31355636]
[http://dx.doi.org/10.1039/C8DT04350G] [PMID: 30702097]
[http://dx.doi.org/10.1039/C5DT00169B] [PMID: 25797411]
[http://dx.doi.org/10.1016/0009-2797(78)90128-X] [PMID: 699174]
[http://dx.doi.org/10.1016/bs.adioch.2019.10.008]
[http://dx.doi.org/10.1021/ar400266c] [PMID: 24555658]
[http://dx.doi.org/10.1016/j.jorganchem.2018.01.008]
[http://dx.doi.org/10.1016/S0020-1693(00)87119-4]
[http://dx.doi.org/10.1016/j.jorganchem.2019.121096]
[http://dx.doi.org/10.1039/C4CC10014J] [PMID: 25605442]
[http://dx.doi.org/10.1002/chem.201601542] [PMID: 27443984]
[http://dx.doi.org/10.1002/ejic.201800225]
[http://dx.doi.org/10.1016/j.bmcl.2013.03.016] [PMID: 23541673]
[http://dx.doi.org/10.1002/chem.201302819] [PMID: 24243420]
[http://dx.doi.org/10.1021/acs.jmedchem.5b01159] [PMID: 26595649]
[http://dx.doi.org/10.1002/ejic.201300820]
[http://dx.doi.org/10.1039/c2ra20967e]
[http://dx.doi.org/10.1016/j.ica.2012.06.046]
[http://dx.doi.org/10.1016/j.canlet.2019.01.018] [PMID: 30673591]
[http://dx.doi.org/10.1002/hlca.201500529]
[http://dx.doi.org/10.1016/j.ica.2019.119061]
[http://dx.doi.org/10.1039/C4CS00063C] [PMID: 24723061]
[http://dx.doi.org/10.1039/b906308k] [PMID: 20449127]
[http://dx.doi.org/10.1021/acs.organomet.5b00586]
[http://dx.doi.org/10.1039/C6DT02350A] [PMID: 27603959]
[http://dx.doi.org/10.1021/jm901693m] [PMID: 20148592]
[http://dx.doi.org/10.1021/jm301780s] [PMID: 23421599]
[http://dx.doi.org/10.1039/C7CC03074F] [PMID: 28653066]
[http://dx.doi.org/10.1021/cr000436x] [PMID: 17580975]
[http://dx.doi.org/10.1021/cr068434l] [PMID: 18613729]
[http://dx.doi.org/10.1021/cr0684319] [PMID: 18636778]
[http://dx.doi.org/10.1021/cr068435d] [PMID: 18651778]
[http://dx.doi.org/10.1021/cr1004088] [PMID: 21314182]
[http://dx.doi.org/10.1021/cr500691k] [PMID: 25844920]
[http://dx.doi.org/10.1021/acs.chemrev.6b00203] [PMID: 27548659]
[http://dx.doi.org/10.1039/C5CS00721F] [PMID: 26673389]
[http://dx.doi.org/10.1039/C6CS00023A] [PMID: 27385433]
[http://dx.doi.org/10.1039/C1CS15279C] [PMID: 22182942]
[http://dx.doi.org/10.1039/b711132k] [PMID: 18762827]
[http://dx.doi.org/10.1002/9783527626724]
[http://dx.doi.org/10.1002/chem.200801992] [PMID: 19025730]
[http://dx.doi.org/10.1016/j.poly.2013.11.039]
[http://dx.doi.org/10.2174/1570180811666140529004102]
[http://dx.doi.org/10.1016/j.jorganchem.2014.09.036]
[http://dx.doi.org/10.1016/j.jorganchem.2019.04.003]
[http://dx.doi.org/10.1016/j.ejmech.2011.10.002] [PMID: 22019187]
[http://dx.doi.org/10.1021/jm201156x] [PMID: 22091836]
[http://dx.doi.org/10.1021/jm3000196] [PMID: 22424185]
[http://dx.doi.org/10.1016/j.jinorgbio.2011.08.026] [PMID: 22112840]
[http://dx.doi.org/10.1002/chem.201604512] [PMID: 27865002]
[http://dx.doi.org/10.1371/journal.pone.0187925] [PMID: 29121120]
[http://dx.doi.org/10.1002/med.21377] [PMID: 26359649]
[http://dx.doi.org/10.1039/C8DT01831F] [PMID: 30207339]
[http://dx.doi.org/10.1016/j.ica.2020.119588]
[http://dx.doi.org/10.1021/ic403011h] [PMID: 24499428]
[http://dx.doi.org/10.1016/j.jorganchem.2014.03.020]
[http://dx.doi.org/10.1007/s00775-015-1283-1] [PMID: 26202908]
[http://dx.doi.org/10.1002/anie.201602702] [PMID: 27311814]
[http://dx.doi.org/10.1002/chem.201705902] [PMID: 29334159]
[http://dx.doi.org/10.1039/C7DT02616A] [PMID: 29192701]
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