摘要
背景:识别与严重急性呼吸系统综合征冠状病毒2(SARS-CoV2)感染和2019冠状病毒病(covid-19)易感性相关的脆弱亚组和危险因素在大流行情景中是至关重要的。肾素-血管紧张素系统(RAS)、免疫标志物和covid-19之间的潜在相互作用在特定患者组的疾病预后中发挥作用。 目的:本文综述了RAS的特殊性和特定亚组患者的免疫系统特征。 方法:本非系统综述总结了SARS-CoV-2在特定患者亚组中感染的证据,以及免疫系统、RAS与covid-19的病理生理学之间可能的关系。 结果:RAS和免疫系统在covid-19的发病机制和预后中发挥作用,主要发生在高血压、糖尿病、肥胖等慢性疾病中。ACE/AngII/AT1R轴的过度激活和炎症的增强导致了covid-19的有害影响。同样,孕妇和老年患者通常对接触病毒的免疫反应效果较差,而儿童相对预防covid-19严重并发症。相反,女性表现出更强的抗病毒反应,并且对AngII增加的影响不那么敏感。 未来的展望:认识到疾病严重程度的脆弱亚组和危险因素对于更好地了解大流行至关重要。精密医学工具,包括蛋白质组学和代谢组学方法,确定了严重形式的疾病的代谢模式,并可能是诊断、评估和预测预后和治疗效率的替代选择。
关键词: Covid-19、RAS、SARS-CoV-2、免疫系统、表型谱、易感组。
Current Medicinal Chemistry
Title:Renin Angiotensin System (RAS) and Immune System Profile in Specific Subgroups with COVID-19
Volume: 28 Issue: 22
关键词: Covid-19、RAS、SARS-CoV-2、免疫系统、表型谱、易感组。
摘要:
Background: The identification of vulnerable subgroups and risk factors associated with the susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV- 2) infection and coronavirus disease 2019 (COVID-19) is of utmost importance in a pandemic scenario. Potential interactions between renin-angiotensin system (RAS), immune markers and COVID-19 play a role in disease outcome in specific groups of patients.
Objective: This review aimed to describe the particularities of the RAS and the immune system profile of particular subgroups of patients.
Methods: This non-systematic review summarizes evidence on SARS-CoV-2 infection in specific subgroups of patients and possible relationships between immune system, RAS and the pathophysiology of COVID-19.
Results: The RAS and the immune system exert a role in the pathogenesis and prognosis of COVID-19, mainly in cases of hypertension, diabetes, obesity and other chronic diseases. The overactivation of the ACE/Ang II/AT1R axis and the enhancement of inflammation contribute to deleterious effects of COVID-19. Likewise, pregnant women and elderly patients usually display immune responses that are less effective in withstanding exposition to viruses, while children are relatively protected against severe complications of COVID-19. Women, conversely, exhibit stronger antiviral responses and are less sensitive to the effects of increased Ang II.
Future Perspectives: The recognition of vulnerable subgroups and risk factors for disease severity is essential to better understand the pandemic. Precision medicine tools, including proteomics and metabolomics approaches, identified metabolic patterns of the severe form of disease and might be the alternative to diagnose, evaluate and predict the prognosis and the efficiency of therapies.
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Renin Angiotensin System (RAS) and Immune System Profile in Specific Subgroups with COVID-19, Current Medicinal Chemistry 2021; 28 (22) . https://dx.doi.org/10.2174/0929867327666200903113117
DOI https://dx.doi.org/10.2174/0929867327666200903113117 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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