Title:Anti-annexin A5, Antiphosphatidylinositol Antibodies, and Haematological Parameters in Preeclampsia Patients: A Case-Control Study
Volume: 17
Issue: 1
Author(s): Wan Haslindawani Wan Mahmood*, Md Asiful Islam, Mimi Azreen Abdullah, Noor Haslina Mohd Noor, Indhira Subbiah, Ahmad Amir Ismail, Mohd Haslan Hassan and Wan Zaidah Abdullah
Affiliation:
- Department of Haematology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan,Malaysia
Keywords:
Preeclampsia, hematological, activated partial thromboplastin time, antiphospholipid, anti-annexin A5, antiphosphatidylinositol.
Abstract:
Background: Prevalence and the risk of common antiphospholipid antibodies (aPLs),
such as lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (β2-GPI) antibodies,
in preeclampsia is a matter of debate. Recently, interests have expanded in evaluating the
risks of presenting non-classic aPLs in preeclampsia patients.
Objective: The objective of this case-control study was to evaluate some hematological parameters
besides assessing the presence of anti-annexin A5 and anti phosphatidylinositol (aPI) antibodies in
preeclampsia patients compared to non-preeclampsia subjects.
Methods: From two hospitals in Malaysia, a total of 84 subjects were recruited in this case-control
study, including 42 preeclampsia and 42 age-matched non-preeclampsia subjects. Some hematological
parameters [i.e., hemoglobin, total white blood cell, platelet, prothrombin time, and activated
partial thromboplastin time (APTT)] were assessed besides screening for anti-annexin A5 and
aPI antibodies.
Results: Among the hematological parameters, APTT was significantly high in mild preeclampsia
when compared to severe preeclampsia subjects (p=0.007). IgG anti-annexin A5 antibody was detected
in a single preeclampsia subject only (2.4%) and none in non-preeclampsia subjects.
Conclusion: Because of the low prevalence, non-classic aPLs should not be considered as a risk
factor in developing preeclampsia and it is not justifiable to consider them as a routine assay in
pregnant women.
