Title:Effect of AnnexinA Group Translocated in Extracellular Vesicles on Tumorigenesis
Volume: 21
Issue: 4
关键词:
分子功能、肿瘤微环境、肿瘤发生、细胞外囊泡、外泌体、膜联蛋白。
摘要: Annexin, a calcium-dependent phospholipid-binding protein, can affect tumor
cell adhesion, proliferation, apoptosis, invasion and metastasis, as well as tumor
neovascularization in different ways. Recent studies have shown that annexin exists not
only as an intracellular protein in tumor cells, but also in different ways to be secret
outside the cell as a “cross-talk” tool for tumor cells and tumor microenvironment, thus
playing an important role in the development of tumors, such as participating in
epithelial-mesenchymal transition, regulating immune cell behavior, promoting
neovascularization and so on. The mechanism of annexin secretion in the form of
extracellular vesicles and its specific role is still unclear. This paper summarizes the
main role of annexin secreted into the extracellular space in the form of extracellular
vesicles in tumorigenesis and drug resistance and analyzes its possible mechanism.
