Title:Cyclotron Production of PET Radiometals in Liquid Targets: Aspects and Prospects
Volume: 14
Issue: 4
Author(s): Mukesh K. Pandey*Timothy R. DeGrado
Affiliation:
- Division of Nuclear Medicine, Department of Radiology, Mayo Clinic Rochester, Minneapolis, 55905,United States
Keywords:
Liquid target, solution target, cyclotron, radiometals, 68Ga, 86Y, 63Zn and 89Zr.
Abstract:
The present review describes the methodological aspects and prospects of the production
of Positron Emission Tomography (PET) radiometals in a liquid target using low-medium energy
medical cyclotrons. The main objective of this review is to delineate and discuss the critical factors
involved in the liquid target production of radiometals, including type of salt solution, solution
composition, beam energy, beam current, the effect of irradiation duration (length of irradiation)
and challenges posed by in-target chemistry in relation with irradiation parameters. We also summarize
the optimal parameters for the production of various radiometals in liquid targets.
Additionally, we discuss the future prospects of PET radiometals production in the liquid targets
for academic research and clinical applications. Significant emphasis has been given to the production
of 68Ga using liquid targets due to the growing demand for 68Ga labeled PSMA vectors, [68Ga]-
Ga-DOTATATE, [68Ga]Ga-DOTANOC and some upcoming 68Ga labeled radiopharmaceuticals.
Other PET radiometals included in the discussion are 86Y, 63Zn and 89Zr.
