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摘要
开发、验证和购买新药的成本正在急剧增加。另一方面,清醒的经济体在维持其医疗体系方面存在困难,特别是在老龄人口需要增加福利的国家。这一难题需要立即采取行动,而一种可能的选择是研究已批准的大量现有药物,并将它们用于创新疗法。这种可能性在肿瘤学中特别有趣,因为肿瘤基因组的复杂性决定了大多数患者采用多步骤治疗方法。在这篇综述中,我们讨论了a)计算方法;b)临床前模型;C)目前正在进行或已经发表的肿瘤学药物再利用领域的临床试验;d)重新利用药物来克服对以前疗法的耐药性。
关键词: 肿瘤学,药物,重新利用, 生物信息学,计算方法,临床前模型,治疗
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