Title:Cancer Proteomics: New Horizons and Insights into Therapeutic Applications
Volume: 18
Issue: 3
Author(s): Perumal Subramanian*, Jaime Jacqueline Jayapalan *Puteri Shafinaz Abdul-Rahman
Affiliation:
- Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Chidambaram 608 002, Tamil Nadu,India
- Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 50603,Malaysia
Keywords:
Proteomics, cancer, pharmacoproteomics, redox proteomics, diagnostic biomarkers, therapeutics.
Abstract: A proteome is an efficient rendition of a genome, unswervingly controlling various cancer
processes. Molecular mechanisms of several cancer processes have been unraveled by the proteomic
approach. Thus far, numerous tumors of diverse status have been investigated by two-dimensional
electrophoresis. Numerous biomarkers have been recognized and precise categorization
of apparent lesions has led to the timely detection of various cancers in persons at peril. Currently
used pioneering approaches and technologies in proteomics have led to highly sensitive assays of
cancer biomarkers and improved the early diagnosis of various cancers. The discovery of novel
and definite biomarker signatures further widened our perceptive of the disease, and novel potent
drugs and aimed therapeutic outcomes in persistent cancers have emerged. However, a major limitation,
even today, of proteomics is resolving and quantifying the proteins of low abundance. Despite
the rapid development of proteomics technologies and their applications in cancer management,
annulling the shortcomings of present proteomic technologies and the development of better
methods are still desirable. The main objectives of this review are to discuss the developing aspects,
merits and demerits of pharmacoproteomics, redox proteomics, novel approaches and therapies
being used for various types of cancer-based on proteome studies.