Title:Mesenchymal Stem Cell Therapy for Oral Inflammatory Diseases: Research Progress and Future Perspectives
Volume: 16
Issue: 2
Author(s): Wang Gong, Fei Wang, Yuqing He, Xin Zeng, Dunfang Zhang*Qianming Chen
Affiliation:
- State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041,China
Keywords:
Mesenchymal Stem Cells (MSCs), Oral Diseases, Stem cell differentiation, Oral inflammation, Immune regulation,
MSC Therapy.
Abstract: Mesenchymal stem cell (MSC) therapy for clinical diseases associated with inflammation
and tissue damage has become a progressive treatment strategy. MSCs have unique biological functions,
such as homing, immune regulation, and differentiation capabilities, which provide the prerequisites
for the treatment of clinical diseases. Oral diseases are often associated with abnormal immune
regulation and epithelial tissue damage. In this review, we summarize previous studies that use MSC
therapy to treat various oral inflammatory diseases, including oral ulceration, allergic diseases,
chemo/radiotherapy-induced oral mucositis, periodontitis, osteonecrosis of the jaw, Sjögren's syndrome
(SS), among other similar diseases. We highlight MSC treatment as a promising approach in the
management of oral inflammatory diseases, and discuss the obstacles that remain and must be overcome
for MSC treatment to thrive in the future.
