Abstract
A simple and efficient protocol has been established to the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones via Knoevenagel condensation reaction. In this synthesis, succinic acid was used as an inexpensive catalyst and water as a green reaction medium. This method is useful for the preparat ion of various derivatives of 3,4-disubstituted isoxazol-5(4H)-ones in excellent yields.
Keywords: Succinic acid, 3, 4-disubstituted isoxazol-5(4H)-ones, Aromatic aldehydes, Ethyl acetoacetate, hydroxylamine hydrochloride, Knoevenagel condensation.
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