Title:Development and Characterization of LBG-PVA Interpenetrating Networks Incorporating Gliclazide for Sustained Release
Volume: 16
Issue: 1
Author(s): Ashish Katoch, Manju Nagpal*, Malkiet Kaur, Manjinder Singh, Geeta Aggarwal and Gitika Arora Dhingra
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Chandigarh Punjab,India
Keywords:
Sustained, interpenetrating networks, cross-linker, networks, bioavailability, dissolution.
Abstract:
Background: Controlled oral dosage forms have always been preferred for drugs with
variable absorption, and short biological half life and frequent dosing. The prime goal with sustained
release systems is to maintain uniform therapeutic blood levels for more extended periods of
time. Interpenetrating networks (IPNs) have been evidenced as uniform sustained release systems.
In the current study, polyvinyl alcohol (PVA) and locust bean gum (LBG) based IPNs were developed
for the oral sustained release drug delivery of gliclazide (shows variable absorption).
Methods: The IPNs were synthesized by emulsion cross-linking method using glutaraldehyde (GA)
as a cross linking agent. Gliclazide is a potential second generation, and short-acting sulfonylurea
oral hypoglycemic agent having a short biological half-life (2-4 h), variable absorption and poor
oral bioavailability. Various batches of IPNs were formulated by varying LBG: PVA ratio and
evaluated for percentage yield, drug entrapment efficiency (DEE), swelling properties and in vitro
drug release studies. Further characterizations were done by Fourier Transform Infrared Spectroscopy
(FTIR), C13 Solid state NMR, X-Ray diffraction study (XRD), Scanning electron microscopy
(SEM), and Differential scanning microscopy (DSC) studies.
Results: The percentage yield, drug entrapment and equilibrium swelling were observed to be dependent
on PVA-LBG ratio and GA amount. Sustained release of drug was observed in all IPN
formulations (approx 59 - 86% in 8 h in various batches) with variable release kinetics. SEM studies
revealed the regular structures of IPNs. FTIR, XRD, C13 Solid state NMR and DSC studies
proposed that drug was successfully incorporated into the formed IPNs.
Conclusion: IPNs of LBG and PVA can be used as a promising carrier with uniform sustained release
characteristics.
