Title:The Regulation of E3 Ubiquitin Ligases Cbl and its Cross-talking in Bone Homeostasis
Volume: 16
Issue: 6
Author(s): Xiaobin Yang, Dingjun Hao* Baorong He*
Affiliation:
- Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an, Shaanxi,China
- Department of Spine Surgery, Honghui Hospital, School of Medicine, Xi’an Jiaotong University, Xi'an, Shaanxi,China
Keywords:
E3 ubiquitin ligases, Cbl, PI3K, Src, bone homeostasis, osteoclast.
Abstract: The E3 ubiquitin ligases Cbl has been found play an important role in regulating cellular
proliferation and migration. Whereas, the excessive differentiation of osteoclast and/or its overexpressing
of resorptive functions could lead the pathological bone homeostasis by overly bone matrix degradation.
Since the first time of the important role of Cbl in the regulating osteoclast differentiation (also
named osteoclastogenesis) has been reported in decades ago. The extensively studies have been conducted
for in-depth exploring Cbl’s definite role during osteoclastogenesis, as well as its cross talking
with other signaling pathways (such as: Src and PI3K signaling) in bone homeostasis. Herein, our current
study aims to briefly conclude the current studies of osteoclastogenesis and the regulatory role of
Cbl, as well as its cross-talking in bone homeostasis.
